Drug interactions
Amisulpride + Tizanidine
Severity: Moderate
Amisulpride and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine can cause sedation and hypotension and amisulpride may add drowsiness, so combined use may reduce alertness. Both drugs can also lower heart rate or blood pressure, and amisulpride prolongs the QT interval, which makes hypotension and bradycardia clinically relevant.
What this interaction means in plain words
Amisulpride and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hypotension from alpha-2 agonism and dopamine antagonism with some adrenergic effects.
What to do
Monitor sedation, blood pressure and heart rate, and use low starting doses. Keep QT risk factors and electrolytes in check.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Tizanidine?
MediHelp rates the interaction as moderate. Amisulpride and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine can cause sedation and hypotension and amisulpride may add drowsiness, so combined use may reduce alertness. Both drugs can also lower heart rate or blood pressure, and amisulpride prolongs the QT interval, which makes hypotension and bradycardia clinically relevant.
How serious is the interaction between Amisulpride and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and heart rate, and use low starting doses. Keep QT risk factors and electrolytes in check.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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