Drug interactions
Amlodipine-atorvastatin + Aprepitant
Severity: Minor
Amlodipine-atorvastatin and Aprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and can raise exposure to CYP3A4 substrates such as amlodipine and atorvastatin. The effect is usually modest and short-lived with standard antiemetic regimens, but it may cause more hypotension, edema or statin-related muscle effects.
What this interaction means in plain words
Amlodipine-atorvastatin and Aprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-atorvastatin belongs to Cardiovascular; Aprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant inhibits CYP3A4, reducing the metabolism of amlodipine and atorvastatin.
What to do
No routine dose change is needed for a short aprepitant course; monitor blood pressure and ask about muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-atorvastatin and Aprepitant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-atorvastatin
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Amlodipine-atorvastatin with Aprepitant?
MediHelp rates the interaction as minor. Amlodipine-atorvastatin and Aprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant is a moderate CYP3A4 inhibitor and can raise exposure to CYP3A4 substrates such as amlodipine and atorvastatin. The effect is usually modest and short-lived with standard antiemetic regimens, but it may cause more hypotension, edema or statin-related muscle effects.
How serious is the interaction between Amlodipine-atorvastatin and Aprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for a short aprepitant course; monitor blood pressure and ask about muscle pain or weakness.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
