Drug interactions
Amlodipine-atorvastatin + Ceritinib
Severity: Moderate
Amlodipine-atorvastatin and Ceritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise concentrations of amlodipine and atorvastatin, both CYP3A4 substrates. This could cause hypotension, edema or statin-related muscle toxicity.
What this interaction means in plain words
Amlodipine-atorvastatin and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Ceritinib belongs to Oncology.
Why it happens
Ceritinib inhibits CYP3A4, reducing metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and for myalgia or weakness, and consider a lower atorvastatin dose or checking CK if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Ceritinib?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may raise concentrations of amlodipine and atorvastatin, both CYP3A4 substrates. This could cause hypotension, edema or statin-related muscle toxicity.
How serious is the interaction between Amlodipine-atorvastatin and Ceritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for myalgia or weakness, and consider a lower atorvastatin dose or checking CK if symptoms appear.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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