Drug interactions
Amlodipine-atorvastatin + Finerenone
Severity: Moderate
Amlodipine-atorvastatin and Finerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may modestly raise finerenone exposure. This could increase the risk of hyperkalemia and reduced renal function.
What this interaction means in plain words
Amlodipine-atorvastatin and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Finerenone belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by amlodipine reduces the metabolism of finerenone, a CYP3A4 substrate.
What to do
Check serum potassium and renal function when starting or adjusting either drug. Adjust the finerenone dose according to potassium results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Finerenone?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may modestly raise finerenone exposure. This could increase the risk of hyperkalemia and reduced renal function.
How serious is the interaction between Amlodipine-atorvastatin and Finerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function when starting or adjusting either drug. Adjust the finerenone dose according to potassium results.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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