Drug interactions
Amlodipine-atorvastatin + Idelalisib
Severity: Major
Amlodipine-atorvastatin and Idelalisib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor that can substantially raise amlodipine and atorvastatin concentrations. This increases risk of hypotension, edema and statin-induced myopathy including rhabdomyolysis.
What this interaction means in plain words
Amlodipine-atorvastatin and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A inhibition decreases metabolism of amlodipine and atorvastatin.
What to do
Consider temporarily withholding atorvastatin or using a statin not dependent on CYP3A, and monitor blood pressure and edema. Counsel patients to report muscle pain promptly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-atorvastatin and Idelalisib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-atorvastatin
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Idelalisib?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor that can substantially raise amlodipine and atorvastatin concentrations. This increases risk of hypotension, edema and statin-induced myopathy including rhabdomyolysis.
How serious is the interaction between Amlodipine-atorvastatin and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider temporarily withholding atorvastatin or using a statin not dependent on CYP3A, and monitor blood pressure and edema. Counsel patients to report muscle pain promptly.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
