Drug interactions
Amlodipine-atorvastatin + Lopinavir
Severity: Major
Amlodipine-atorvastatin and Lopinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir boosted with ritonavir strongly inhibits CYP3A4, increasing amlodipine and atorvastatin exposure. This raises the risk of hypotension, edema and statin myopathy.
What this interaction means in plain words
Amlodipine-atorvastatin and Lopinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Lopinavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted lopinavir inhibits CYP3A4, reducing metabolism of both components.
What to do
Use the lowest effective atorvastatin dose and avoid exceeding labeled limits. Monitor blood pressure, edema and muscle symptoms, reducing the amlodipine dose if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Lopinavir?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Lopinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lopinavir boosted with ritonavir strongly inhibits CYP3A4, increasing amlodipine and atorvastatin exposure. This raises the risk of hypotension, edema and statin myopathy.
How serious is the interaction between Amlodipine-atorvastatin and Lopinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective atorvastatin dose and avoid exceeding labeled limits. Monitor blood pressure, edema and muscle symptoms, reducing the amlodipine dose if needed.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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