Drug interactions
Amlodipine-atorvastatin + Nevirapine
Severity: Moderate
Amlodipine-atorvastatin and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may lower amlodipine and atorvastatin concentrations. Blood pressure and cholesterol control may be reduced.
What this interaction means in plain words
Amlodipine-atorvastatin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Nevirapine belongs to Anti Virals.
Why it happens
Induction of CYP3A4 by nevirapine increases the metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and lipid levels after starting or stopping nevirapine. Titrate amlodipine and atorvastatin doses to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Amlodipine-atorvastatin with Nevirapine?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and may lower amlodipine and atorvastatin concentrations. Blood pressure and cholesterol control may be reduced.
How serious is the interaction between Amlodipine-atorvastatin and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and lipid levels after starting or stopping nevirapine. Titrate amlodipine and atorvastatin doses to response.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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