Drug interactions
Amlodipine-atorvastatin + Rucaparib
Severity: Minor
Amlodipine-atorvastatin and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak CYP3A4 inhibitor and may slightly increase exposure to amlodipine and atorvastatin. Clinical consequences are expected to be small.
What this interaction means in plain words
Amlodipine-atorvastatin and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-atorvastatin belongs to Cardiovascular; Rucaparib belongs to Oncology.
Why it happens
Rucaparib weakly inhibits CYP3A4, reducing metabolism of CYP3A4 substrates.
What to do
Monitor blood pressure and muscle symptoms during co-treatment. Adjust the dose only if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Amlodipine-atorvastatin with Rucaparib?
MediHelp rates the interaction as minor. Amlodipine-atorvastatin and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak CYP3A4 inhibitor and may slightly increase exposure to amlodipine and atorvastatin. Clinical consequences are expected to be small.
How serious is the interaction between Amlodipine-atorvastatin and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and muscle symptoms during co-treatment. Adjust the dose only if adverse effects appear.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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