Drug interactions
Amlodipine-atorvastatin + Temsirolimus
Severity: Moderate
Amlodipine-atorvastatin and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus is an mTOR inhibitor that can cause angioedema, and calcium channel blockers such as amlodipine have been associated with a higher frequency of this reaction when given together. Swelling of the face, lips, tongue or airway may occur and can be serious.
What this interaction means in plain words
Amlodipine-atorvastatin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
The mechanism is not firmly established; additive predisposition to angioedema is proposed, possibly involving impaired bradykinin handling.
What to do
Counsel the patient to report any swelling of the face, lips, tongue or throat immediately. Stop temsirolimus and treat if angioedema develops, and consider an alternative antihypertensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Temsirolimus?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus is an mTOR inhibitor that can cause angioedema, and calcium channel blockers such as amlodipine have been associated with a higher frequency of this reaction when given together. Swelling of the face, lips, tongue or airway may occur and can be serious.
How serious is the interaction between Amlodipine-atorvastatin and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report any swelling of the face, lips, tongue or throat immediately. Stop temsirolimus and treat if angioedema develops, and consider an alternative antihypertensive.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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