Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Silodosin
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Silodosin is an alpha-1A blocker that can cause orthostatic hypotension and dizziness. Combined with a three-drug antihypertensive product, blood pressure lowering is additive, especially after the first doses or dose increases.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive vasodilatory and blood pressure lowering pharmacodynamic effects.
What to do
Start silodosin at the lowest dose and advise slow postural changes. Monitor standing and sitting blood pressure and adjust antihypertensives if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Silodosin?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Silodosin is an alpha-1A blocker that can cause orthostatic hypotension and dizziness. Combined with a three-drug antihypertensive product, blood pressure lowering is additive, especially after the first doses or dose increases.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start silodosin at the lowest dose and advise slow postural changes. Monitor standing and sitting blood pressure and adjust antihypertensives if symptomatic.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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