Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Avanafil
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Avanafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a PDE5 inhibitor with vasodilatory effects and can lower blood pressure. In patients taking several antihypertensives, including amlodipine, symptomatic hypotension is more likely.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Avanafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and antihypertensive drugs.
What to do
Ensure blood pressure is stable before starting avanafil and use the lowest dose. Counsel patients to report dizziness or fainting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Avanafil?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a PDE5 inhibitor with vasodilatory effects and can lower blood pressure. In patients taking several antihypertensives, including amlodipine, symptomatic hypotension is more likely.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Avanafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure blood pressure is stable before starting avanafil and use the lowest dose. Counsel patients to report dizziness or fainting.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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