Drug interactions
Amlodipine-perindopril + Amobarbital
Severity: Moderate
Amlodipine-perindopril and Amobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and may lower amlodipine concentrations, potentially reducing antihypertensive effect. Barbiturates can also add to hypotension.
What this interaction means in plain words
Amlodipine-perindopril and Amobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Amobarbital belongs to Central Nervous System.
Why it happens
Amobarbital induces hepatic CYP3A4, increasing amlodipine metabolism.
What to do
Monitor blood pressure after starting or stopping the barbiturate and increase the amlodipine dose if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Amobarbital?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Amobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and may lower amlodipine concentrations, potentially reducing antihypertensive effect. Barbiturates can also add to hypotension.
How serious is the interaction between Amlodipine-perindopril and Amobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping the barbiturate and increase the amlodipine dose if control is inadequate.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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