Drug interactions
Amlodipine-perindopril + Avapritinib
Severity: Minor
Amlodipine-perindopril and Avapritinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib is metabolized by CYP3A4, and amlodipine is only a weak inhibitor of this enzyme. Avapritinib levels may increase slightly, with a possible increase in cognitive effects, edema and bleeding risk.
What this interaction means in plain words
Amlodipine-perindopril and Avapritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Avapritinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by amlodipine may slightly reduce avapritinib clearance.
What to do
No empirical dose adjustment is needed. Monitor for avapritinib toxicity such as cognitive changes, peripheral edema and bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-perindopril and Avapritinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Amlodipine-perindopril with Avapritinib?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Avapritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Avapritinib is metabolized by CYP3A4, and amlodipine is only a weak inhibitor of this enzyme. Avapritinib levels may increase slightly, with a possible increase in cognitive effects, edema and bleeding risk.
How serious is the interaction between Amlodipine-perindopril and Avapritinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed. Monitor for avapritinib toxicity such as cognitive changes, peripheral edema and bleeding.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
