Drug interactions
Amlodipine-perindopril + Carbamazepine
Severity: Moderate
Amlodipine-perindopril and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces CYP3A4 and can lower amlodipine concentrations, reducing blood pressure control. The effect may emerge gradually after carbamazepine is started or when its dose is increased.
What this interaction means in plain words
Amlodipine-perindopril and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Carbamazepine belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP3A4, increasing the metabolism of amlodipine.
What to do
Monitor blood pressure after starting or stopping carbamazepine and increase the amlodipine dose if needed. Reduce the dose again if carbamazepine is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Carbamazepine?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces CYP3A4 and can lower amlodipine concentrations, reducing blood pressure control. The effect may emerge gradually after carbamazepine is started or when its dose is increased.
How serious is the interaction between Amlodipine-perindopril and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping carbamazepine and increase the amlodipine dose if needed. Reduce the dose again if carbamazepine is withdrawn.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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