Drug interactions
Amlodipine-perindopril + Clarithromycin
Severity: Moderate
Amlodipine-perindopril and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin raises amlodipine exposure and has been linked with hypotension and acute kidney injury in patients taking calcium channel blockers metabolised by CYP3A4. Older adults are at greater risk.
What this interaction means in plain words
Amlodipine-perindopril and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Clarithromycin belongs to Anti Bacterial.
Why it happens
Clarithromycin inhibits CYP3A4 and intestinal P-glycoprotein, decreasing amlodipine clearance.
What to do
Monitor blood pressure and renal function during the antibiotic course, or choose a non-CYP3A4-inhibiting macrolide such as azithromycin when appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Clarithromycin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin raises amlodipine exposure and has been linked with hypotension and acute kidney injury in patients taking calcium channel blockers metabolised by CYP3A4. Older adults are at greater risk.
How serious is the interaction between Amlodipine-perindopril and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during the antibiotic course, or choose a non-CYP3A4-inhibiting macrolide such as azithromycin when appropriate.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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