Drug interactions
Amlodipine-perindopril + Clevidipine
Severity: Moderate
Amlodipine-perindopril and Clevidipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both amlodipine and clevidipine are dihydropyridine calcium channel blockers, so combining them duplicates therapy. This increases the risk of marked hypotension and reflex tachycardia.
What this interaction means in plain words
Amlodipine-perindopril and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Clevidipine belongs to Cardiovascular.
Why it happens
Additive L-type calcium channel blockade and vasodilation.
What to do
Titrate intravenous clevidipine against continuous blood pressure monitoring in patients on oral amlodipine. Start at a lower infusion rate and adjust the doses carefully.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Amlodipine-perindopril with Clevidipine?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both amlodipine and clevidipine are dihydropyridine calcium channel blockers, so combining them duplicates therapy. This increases the risk of marked hypotension and reflex tachycardia.
How serious is the interaction between Amlodipine-perindopril and Clevidipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate intravenous clevidipine against continuous blood pressure monitoring in patients on oral amlodipine. Start at a lower infusion rate and adjust the doses carefully.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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