Drug interactions
Amlodipine-perindopril + Crizotinib
Severity: Moderate
Amlodipine-perindopril and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may raise amlodipine concentrations, leading to hypotension, edema or bradycardia. Crizotinib itself can cause bradycardia, so the combination may compound this effect.
What this interaction means in plain words
Amlodipine-perindopril and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Crizotinib belongs to Oncology.
Why it happens
Crizotinib is a moderate CYP3A4 inhibitor that reduces amlodipine metabolism; additive bradycardic effects are also possible.
What to do
Monitor heart rate and blood pressure, and reduce the amlodipine dose if hypotension or marked edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Crizotinib?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib may raise amlodipine concentrations, leading to hypotension, edema or bradycardia. Crizotinib itself can cause bradycardia, so the combination may compound this effect.
How serious is the interaction between Amlodipine-perindopril and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and reduce the amlodipine dose if hypotension or marked edema develops.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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