Drug interactions
Amlodipine-perindopril + Dalteparin
Severity: Moderate
Amlodipine-perindopril and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins, including dalteparin, can suppress aldosterone secretion and cause hyperkalemia, which may be amplified by an ACE inhibitor such as perindopril. The risk is greater in renal impairment, diabetes and prolonged therapy.
What this interaction means in plain words
Amlodipine-perindopril and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Dalteparin belongs to Cardiovascular.
Why it happens
Heparin-induced suppression of adrenal aldosterone synthesis adds to the potassium-retaining effect of ACE inhibition.
What to do
Check serum potassium at baseline and periodically, especially if therapy exceeds several days or renal function is reduced. Treat hyperkalemia or reconsider therapy if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Amlodipine-perindopril with Dalteparin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins, including dalteparin, can suppress aldosterone secretion and cause hyperkalemia, which may be amplified by an ACE inhibitor such as perindopril. The risk is greater in renal impairment, diabetes and prolonged therapy.
How serious is the interaction between Amlodipine-perindopril and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium at baseline and periodically, especially if therapy exceeds several days or renal function is reduced. Treat hyperkalemia or reconsider therapy if potassium rises.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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