Drug interactions
Amlodipine-perindopril + Eplerenone
Severity: Major
Amlodipine-perindopril and Eplerenone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eplerenone and ACE inhibitors both reduce potassium excretion and together can cause significant hyperkalemia. Risk is greater in renal impairment, diabetes and older age.
What this interaction means in plain words
Amlodipine-perindopril and Eplerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-perindopril belongs to Cardiovascular; Eplerenone belongs to Cardiovascular.
Why it happens
Additive suppression of the renin-angiotensin-aldosterone axis, with aldosterone receptor blockade plus reduced angiotensin II.
What to do
Check potassium and creatinine at baseline, within the first week, and regularly afterwards; adjust or stop eplerenone if potassium rises significantly and avoid potassium supplements.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Eplerenone?
MediHelp rates the interaction as major. Amlodipine-perindopril and Eplerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eplerenone and ACE inhibitors both reduce potassium excretion and together can cause significant hyperkalemia. Risk is greater in renal impairment, diabetes and older age.
How serious is the interaction between Amlodipine-perindopril and Eplerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and creatinine at baseline, within the first week, and regularly afterwards; adjust or stop eplerenone if potassium rises significantly and avoid potassium supplements.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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