Drug interactions
Amlodipine-perindopril + Ethacrynic acid
Severity: Moderate
Amlodipine-perindopril and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as ethacrynic acid cause volume depletion, and adding an ACE inhibitor like perindopril can produce sudden hypotension and a decline in renal function. The risk is highest at initiation, in volume-depleted patients, and in those with renal impairment.
What this interaction means in plain words
Amlodipine-perindopril and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive hypotensive effect, as diuretic-induced volume and sodium depletion increases dependence on angiotensin II and ACE inhibition removes it.
What to do
Monitor blood pressure, renal function and electrolytes after starting or increasing either drug. Consider temporarily reducing the diuretic dose before starting perindopril.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-perindopril and Ethacrynic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Amlodipine-perindopril with Ethacrynic acid?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as ethacrynic acid cause volume depletion, and adding an ACE inhibitor like perindopril can produce sudden hypotension and a decline in renal function. The risk is highest at initiation, in volume-depleted patients, and in those with renal impairment.
How serious is the interaction between Amlodipine-perindopril and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after starting or increasing either drug. Consider temporarily reducing the diuretic dose before starting perindopril.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
