Drug interactions
Amlodipine-perindopril + Flibanserin
Severity: Moderate
Amlodipine-perindopril and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may modestly increase flibanserin exposure, raising the risk of hypotension, syncope and sedation. The risk is greater when several weak inhibitors are used together or when alcohol is consumed.
What this interaction means in plain words
Amlodipine-perindopril and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Flibanserin belongs to Genitourinary.
Why it happens
Weak inhibition of CYP3A4 by amlodipine reduces flibanserin metabolism.
What to do
Monitor for dizziness, sedation and hypotension, and advise the patient to avoid alcohol around flibanserin dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Flibanserin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may modestly increase flibanserin exposure, raising the risk of hypotension, syncope and sedation. The risk is greater when several weak inhibitors are used together or when alcohol is consumed.
How serious is the interaction between Amlodipine-perindopril and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, sedation and hypotension, and advise the patient to avoid alcohol around flibanserin dosing.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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