Drug interactions
Amlodipine-perindopril + Fluphenazine
Severity: Minor
Amlodipine-perindopril and Fluphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine has alpha-adrenergic blocking activity that can add to the blood pressure lowering of antihypertensives. Orthostatic hypotension and dizziness may be more pronounced, especially in older patients.
What this interaction means in plain words
Amlodipine-perindopril and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effect from alpha-1 blockade by the phenothiazine.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting fluphenazine; reduce antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Amlodipine-perindopril with Fluphenazine?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluphenazine has alpha-adrenergic blocking activity that can add to the blood pressure lowering of antihypertensives. Orthostatic hypotension and dizziness may be more pronounced, especially in older patients.
How serious is the interaction between Amlodipine-perindopril and Fluphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting fluphenazine; reduce antihypertensive dose if hypotension occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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