Drug interactions
Amlodipine-perindopril + Furosemide
Severity: Moderate
Amlodipine-perindopril and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an ACE inhibitor to a patient on a loop diuretic can cause marked first-dose hypotension, especially if volume depleted. Acute renal impairment may also occur.
What this interaction means in plain words
Amlodipine-perindopril and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Furosemide belongs to Cardiovascular.
Why it happens
Diuretic-induced volume and sodium depletion makes blood pressure and glomerular filtration dependent on angiotensin II, which ACE inhibition removes.
What to do
Consider reducing or temporarily holding furosemide before starting perindopril, and check blood pressure, creatinine and potassium within one to two weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-perindopril and Furosemide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Amlodipine-perindopril with Furosemide?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding an ACE inhibitor to a patient on a loop diuretic can cause marked first-dose hypotension, especially if volume depleted. Acute renal impairment may also occur.
How serious is the interaction between Amlodipine-perindopril and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing or temporarily holding furosemide before starting perindopril, and check blood pressure, creatinine and potassium within one to two weeks.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
