Drug interactions
Amlodipine-perindopril + Iloperidone
Severity: Moderate
Amlodipine-perindopril and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has alpha-1 blocking activity and causes orthostatic hypotension. Combined with antihypertensives like amlodipine and perindopril, hypotension, dizziness and syncope may be increased.
What this interaction means in plain words
Amlodipine-perindopril and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Iloperidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade and vasodilation.
What to do
Monitor blood pressure and orthostatic symptoms, especially during iloperidone titration. Reduce antihypertensive doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Amlodipine-perindopril with Iloperidone?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone has alpha-1 blocking activity and causes orthostatic hypotension. Combined with antihypertensives like amlodipine and perindopril, hypotension, dizziness and syncope may be increased.
How serious is the interaction between Amlodipine-perindopril and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially during iloperidone titration. Reduce antihypertensive doses if hypotension occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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