Drug interactions
Amlodipine-perindopril + Itraconazole
Severity: Major
Amlodipine-perindopril and Itraconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole inhibits CYP3A4 and can raise amlodipine exposure, leading to hypotension and peripheral edema. Itraconazole also has negative inotropic effects that may add to those of calcium channel blockers, which matters in patients with heart failure.
What this interaction means in plain words
Amlodipine-perindopril and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-perindopril belongs to Cardiovascular; Itraconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by itraconazole reduces amlodipine clearance, with additive negative inotropy.
What to do
Monitor blood pressure, edema and signs of heart failure, and reduce the amlodipine dose if needed. Consider an alternative antifungal in patients with left ventricular dysfunction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Itraconazole?
MediHelp rates the interaction as major. Amlodipine-perindopril and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole inhibits CYP3A4 and can raise amlodipine exposure, leading to hypotension and peripheral edema. Itraconazole also has negative inotropic effects that may add to those of calcium channel blockers, which matters in patients with heart failure.
How serious is the interaction between Amlodipine-perindopril and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and signs of heart failure, and reduce the amlodipine dose if needed. Consider an alternative antifungal in patients with left ventricular dysfunction.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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