Drug interactions
Amlodipine-perindopril + Lurasidone
Severity: Moderate
Amlodipine-perindopril and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause orthostatic hypotension through alpha-adrenergic blockade, which adds to the effects of amlodipine and perindopril. Patients may experience dizziness, syncope or falls, particularly at initiation or dose increases.
What this interaction means in plain words
Amlodipine-perindopril and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive blood pressure lowering from alpha-1 adrenergic antagonism by lurasidone and the vasodilating effects of the antihypertensives.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating lurasidone. Lower the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Lurasidone?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause orthostatic hypotension through alpha-adrenergic blockade, which adds to the effects of amlodipine and perindopril. Patients may experience dizziness, syncope or falls, particularly at initiation or dose increases.
How serious is the interaction between Amlodipine-perindopril and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating lurasidone. Lower the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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