Drug interactions
Amlodipine-perindopril + Mefloquine
Severity: Moderate
Amlodipine-perindopril and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine may affect cardiac conduction and cause bradycardia or other rhythm disturbances, which could be additive with the hemodynamic effects of calcium channel blockers. Any increase in amlodipine exposure is not well established.
What this interaction means in plain words
Amlodipine-perindopril and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible additive effects on cardiac conduction and blood pressure; a pharmacokinetic effect on amlodipine metabolism is unproven.
What to do
Monitor heart rate, blood pressure and ECG if clinically indicated when the two are given together. Consider alternative antimalarials in patients with conduction abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Mefloquine?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine may affect cardiac conduction and cause bradycardia or other rhythm disturbances, which could be additive with the hemodynamic effects of calcium channel blockers. Any increase in amlodipine exposure is not well established.
How serious is the interaction between Amlodipine-perindopril and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG if clinically indicated when the two are given together. Consider alternative antimalarials in patients with conduction abnormalities.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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