Drug interactions
Amlodipine-perindopril + Nisoldipine
Severity: Moderate
Amlodipine-perindopril and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine and nisoldipine are both dihydropyridine calcium channel blockers, so using them together duplicates therapy and adds to blood pressure lowering. This increases the likelihood of hypotension, dizziness, peripheral edema and reflex tachycardia without clear added benefit.
What this interaction means in plain words
Amlodipine-perindopril and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Nisoldipine belongs to Cardiovascular.
Why it happens
Therapeutic duplication with additive L-type calcium channel blockade causing vasodilation.
What to do
Avoid combining two dihydropyridines; discontinue nisoldipine or use a different antihypertensive class if more control is needed. If both are given temporarily, monitor blood pressure and edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Amlodipine-perindopril with Nisoldipine?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine and nisoldipine are both dihydropyridine calcium channel blockers, so using them together duplicates therapy and adds to blood pressure lowering. This increases the likelihood of hypotension, dizziness, peripheral edema and reflex tachycardia without clear added benefit.
How serious is the interaction between Amlodipine-perindopril and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two dihydropyridines; discontinue nisoldipine or use a different antihypertensive class if more control is needed. If both are given temporarily, monitor blood pressure and edema.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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