Drug interactions
Amlodipine-perindopril + Simvastatin
Severity: Moderate
Amlodipine-perindopril and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine modestly raises simvastatin exposure, which increases the risk of myopathy and rhabdomyolysis. The labeling limits the simvastatin dose when it is combined with amlodipine.
What this interaction means in plain words
Amlodipine-perindopril and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Simvastatin belongs to Cardiovascular.
Why it happens
Amlodipine weakly inhibits CYP3A4-mediated metabolism of simvastatin, increasing systemic exposure to simvastatin and its active acid.
What to do
Limit simvastatin to 20 mg daily, or switch to a statin less dependent on CYP3A4 such as rosuvastatin or pravastatin. Advise patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
- Darunavir + Simvastatin Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Simvastatin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine modestly raises simvastatin exposure, which increases the risk of myopathy and rhabdomyolysis. The labeling limits the simvastatin dose when it is combined with amlodipine.
How serious is the interaction between Amlodipine-perindopril and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit simvastatin to 20 mg daily, or switch to a statin less dependent on CYP3A4 such as rosuvastatin or pravastatin. Advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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