Drug interactions
Amlodipine-perindopril + Sirolimus
Severity: Major
Amlodipine-perindopril and Sirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors combined with mTOR inhibitors such as sirolimus are associated with a higher incidence of angioedema. Amlodipine may also modestly raise sirolimus exposure. Angioedema can involve the airway and be dangerous.
What this interaction means in plain words
Amlodipine-perindopril and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-perindopril belongs to Cardiovascular; Sirolimus belongs to Miscellaneous.
Why it happens
Both ACE inhibition (bradykinin accumulation) and mTOR inhibition impair pathways of kinin degradation, additively raising angioedema risk.
What to do
Counsel patients to seek urgent care for swelling of the lips, tongue or throat. Consider an alternative antihypertensive class, and stop the ACE inhibitor if angioedema occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Sirolimus?
MediHelp rates the interaction as major. Amlodipine-perindopril and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors combined with mTOR inhibitors such as sirolimus are associated with a higher incidence of angioedema. Amlodipine may also modestly raise sirolimus exposure. Angioedema can involve the airway and be dangerous.
How serious is the interaction between Amlodipine-perindopril and Sirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to seek urgent care for swelling of the lips, tongue or throat. Consider an alternative antihypertensive class, and stop the ACE inhibitor if angioedema occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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