Drug interactions
Amlodipine-perindopril + Succinylcholine
Severity: Minor
Amlodipine-perindopril and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers may modestly prolong or intensify neuromuscular blockade from succinylcholine. Hypotension during anesthesia can also be additive.
What this interaction means in plain words
Amlodipine-perindopril and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Calcium channel blockade may impair neuromuscular transmission, adding to depolarizing blockade.
What to do
Monitor neuromuscular function and blood pressure perioperatively and titrate the blocker to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Amlodipine-perindopril with Succinylcholine?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers may modestly prolong or intensify neuromuscular blockade from succinylcholine. Hypotension during anesthesia can also be additive.
How serious is the interaction between Amlodipine-perindopril and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function and blood pressure perioperatively and titrate the blocker to effect.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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