Drug interactions
Amlodipine-perindopril + Tacrolimus
Severity: Moderate
Amlodipine-perindopril and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine may modestly increase tacrolimus blood concentrations, probably through weak CYP3A inhibition, increasing the risk of nephrotoxicity and other adverse effects. The effect varies between patients.
What this interaction means in plain words
Amlodipine-perindopril and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Probable weak inhibition of CYP3A4/P-glycoprotein-mediated tacrolimus metabolism by amlodipine.
What to do
Monitor tacrolimus trough levels and renal function when amlodipine is started, stopped or changed. Adjust the tacrolimus dose to the trough level.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Tacrolimus?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine may modestly increase tacrolimus blood concentrations, probably through weak CYP3A inhibition, increasing the risk of nephrotoxicity and other adverse effects. The effect varies between patients.
How serious is the interaction between Amlodipine-perindopril and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function when amlodipine is started, stopped or changed. Adjust the tacrolimus dose to the trough level.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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