Drug interactions
Amlodipine-perindopril + Tazemetostat
Severity: Minor
Amlodipine-perindopril and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and may modestly reduce amlodipine exposure. Amlodipine is a weak CYP3A4 inhibitor, so tazemetostat levels could increase slightly, but the clinical significance is likely small.
What this interaction means in plain words
Amlodipine-perindopril and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4, increasing amlodipine clearance, and amlodipine weakly inhibits CYP3A4.
What to do
Monitor blood pressure after starting tazemetostat and adjust amlodipine if control worsens. No tazemetostat dose change is normally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Amlodipine-perindopril with Tazemetostat?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak-to-moderate CYP3A4 inducer and may modestly reduce amlodipine exposure. Amlodipine is a weak CYP3A4 inhibitor, so tazemetostat levels could increase slightly, but the clinical significance is likely small.
How serious is the interaction between Amlodipine-perindopril and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting tazemetostat and adjust amlodipine if control worsens. No tazemetostat dose change is normally needed.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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