Drug interactions
Amlodipine-perindopril + Torsemide
Severity: Moderate
Amlodipine-perindopril and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as torsemide cause volume depletion, and adding an ACE inhibitor can produce marked first-dose hypotension and reduced renal function. Amlodipine adds further blood pressure lowering.
What this interaction means in plain words
Amlodipine-perindopril and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Why it happens
Diuretic-induced volume and sodium depletion activates the renin-angiotensin system, so ACE inhibition causes exaggerated hypotension and reduced glomerular filtration.
What to do
Consider temporarily lowering or holding torsemide before starting perindopril in volume-depleted patients. Monitor blood pressure, creatinine and potassium after initiation or dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Torsemide
Frequently asked questions
Can I take Amlodipine-perindopril with Torsemide?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as torsemide cause volume depletion, and adding an ACE inhibitor can produce marked first-dose hypotension and reduced renal function. Amlodipine adds further blood pressure lowering.
How serious is the interaction between Amlodipine-perindopril and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider temporarily lowering or holding torsemide before starting perindopril in volume-depleted patients. Monitor blood pressure, creatinine and potassium after initiation or dose changes.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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