Drug interactions
Amobarbital + Chlorpromazine
Severity: Moderate
Amobarbital and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so the combination increases sedation, hypotension and respiratory depression risk. Barbiturates can also reduce chlorpromazine concentrations through enzyme induction, and chlorpromazine may lower the seizure threshold.
What this interaction means in plain words
Amobarbital and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive CNS depression, with barbiturate-mediated induction of hepatic metabolism of chlorpromazine.
What to do
Monitor sedation, blood pressure and psychiatric response, and adjust doses as needed. Take extra care in older or debilitated patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Amobarbital with Chlorpromazine?
MediHelp rates the interaction as moderate. Amobarbital and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so the combination increases sedation, hypotension and respiratory depression risk. Barbiturates can also reduce chlorpromazine concentrations through enzyme induction, and chlorpromazine may lower the seizure threshold.
How serious is the interaction between Amobarbital and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and psychiatric response, and adjust doses as needed. Take extra care in older or debilitated patients.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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