Drug interactions
Amobarbital + Disopyramide
Severity: Moderate
Amobarbital and Disopyramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates can lower disopyramide concentrations, possibly resulting in loss of antiarrhythmic control. Enzyme induction also changes the ratio of disopyramide to its active anticholinergic metabolite.
What this interaction means in plain words
Amobarbital and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Disopyramide belongs to Cardiovascular.
Why it happens
Amobarbital induces CYP3A4, increasing disopyramide metabolism.
What to do
Monitor ECG, arrhythmia control and disopyramide levels when starting or stopping amobarbital, and adjust the disopyramide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Amobarbital with Disopyramide?
MediHelp rates the interaction as moderate. Amobarbital and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates can lower disopyramide concentrations, possibly resulting in loss of antiarrhythmic control. Enzyme induction also changes the ratio of disopyramide to its active anticholinergic metabolite.
How serious is the interaction between Amobarbital and Disopyramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, arrhythmia control and disopyramide levels when starting or stopping amobarbital, and adjust the disopyramide dose as needed.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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