Drug interactions
Amobarbital + Medroxyprogesterone
Severity: Moderate
Amobarbital and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can reduce progestin exposure. With medroxyprogesterone this may lessen contraceptive or hormonal therapy effectiveness, although depot injections are less affected.
What this interaction means in plain words
Amobarbital and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Medroxyprogesterone belongs to Endocrine.
Why it happens
Induction of CYP3A4 by amobarbital increases the metabolism of medroxyprogesterone.
What to do
Monitor for loss of contraceptive or therapeutic effect and use additional or alternative contraception if needed. Consider shorter dosing intervals or other options for oral therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Amobarbital with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Amobarbital and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and can reduce progestin exposure. With medroxyprogesterone this may lessen contraceptive or hormonal therapy effectiveness, although depot injections are less affected.
How serious is the interaction between Amobarbital and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of contraceptive or therapeutic effect and use additional or alternative contraception if needed. Consider shorter dosing intervals or other options for oral therapy.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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