Drug interactions
Amobarbital + Posaconazole
Severity: Moderate
Amobarbital and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are potent enzyme inducers and may lower posaconazole exposure, risking antifungal treatment failure or breakthrough infection. Effect is expected to build over days of barbiturate use.
What this interaction means in plain words
Amobarbital and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Induction of UDP-glucuronidation and efflux transporters (and possibly CYP3A4) by barbiturates increases posaconazole clearance; reduced GI absorption has also been proposed.
What to do
Avoid the combination if possible; if unavoidable, monitor posaconazole trough levels and clinical response and consider dose adjustment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Posaconazole?
MediHelp rates the interaction as moderate. Amobarbital and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are potent enzyme inducers and may lower posaconazole exposure, risking antifungal treatment failure or breakthrough infection. Effect is expected to build over days of barbiturate use.
How serious is the interaction between Amobarbital and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if unavoidable, monitor posaconazole trough levels and clinical response and consider dose adjustment.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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