Drug interactions
Amobarbital + Riluzole
Severity: Minor
Amobarbital and Riluzole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may lower riluzole concentrations via CYP1A2 induction, possibly reducing its effect. Clinical significance is uncertain.
What this interaction means in plain words
Amobarbital and Riluzole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Riluzole belongs to Miscellaneous.
Why it happens
Induction of CYP1A2 may increase riluzole metabolism.
What to do
No routine adjustment is needed; monitor clinical response and liver tests as usual for riluzole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
Frequently asked questions
Can I take Amobarbital with Riluzole?
MediHelp rates the interaction as minor. Amobarbital and Riluzole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amobarbital may lower riluzole concentrations via CYP1A2 induction, possibly reducing its effect. Clinical significance is uncertain.
How serious is the interaction between Amobarbital and Riluzole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor clinical response and liver tests as usual for riluzole.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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