Drug interactions
Amobarbital + Ubrogepant
Severity: Moderate
Amobarbital and Ubrogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may reduce ubrogepant exposure and thus its efficacy in acute migraine. Labeling advises avoiding strong CYP3A4 inducers.
What this interaction means in plain words
Amobarbital and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Ubrogepant belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases ubrogepant metabolism.
What to do
Avoid concurrent use where possible; if used, monitor for loss of efficacy and consider an alternative acute migraine therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Amobarbital with Ubrogepant?
MediHelp rates the interaction as moderate. Amobarbital and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may reduce ubrogepant exposure and thus its efficacy in acute migraine. Labeling advises avoiding strong CYP3A4 inducers.
How serious is the interaction between Amobarbital and Ubrogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if used, monitor for loss of efficacy and consider an alternative acute migraine therapy.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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