Drug interactions
Amoxicillin + Pretomanid
Severity: Moderate
Amoxicillin and Pretomanid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The pretomanid regimen is associated with hepatotoxicity, and other potentially hepatotoxic drugs may add to the risk. Plain amoxicillin has a low hepatotoxic potential, but amoxicillin-clavulanate is more often implicated.
What this interaction means in plain words
Amoxicillin and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amoxicillin belongs to Anti Bacterial; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive potential for hepatotoxicity; no pharmacokinetic mechanism is established.
What to do
Monitor liver enzymes regularly during co-treatment and prefer plain amoxicillin over amoxicillin-clavulanate. Stop the offending agent if liver injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Other interactions of Pretomanid
Frequently asked questions
Can I take Amoxicillin with Pretomanid?
MediHelp rates the interaction as moderate. Amoxicillin and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The pretomanid regimen is associated with hepatotoxicity, and other potentially hepatotoxic drugs may add to the risk. Plain amoxicillin has a low hepatotoxic potential, but amoxicillin-clavulanate is more often implicated.
How serious is the interaction between Amoxicillin and Pretomanid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes regularly during co-treatment and prefer plain amoxicillin over amoxicillin-clavulanate. Stop the offending agent if liver injury develops.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Cholera vaccine. The full list is on the Amoxicillin page.
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