Drug interactions
Amphotericin b liposomal + Oxaliplatin
Severity: Moderate
Amphotericin b liposomal and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B can cause nephrotoxicity, electrolyte loss and infusion reactions. Oxaliplatin could add to renal or infusion-related problems, but the clinical data supporting this are limited.
What this interaction means in plain words
Amphotericin b liposomal and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b liposomal belongs to Anti Fungals; Oxaliplatin belongs to Oncology.
Why it happens
Possible additive nephrotoxicity; the mechanism is not well established.
What to do
Monitor renal function, potassium and magnesium during co-treatment. Watch for infusion reactions such as bronchospasm and hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Amphotericin b liposomal
- Amlodipine-benazepril + Amphotericin b liposomal Moderate
- Amphotericin b liposomal + Benazepril Moderate
- Amphotericin b liposomal + Captopril-hydrochlorothiazide Moderate
- Amphotericin b liposomal + Deflazacort Moderate
- Amphotericin b liposomal + Dichlorphenamide Moderate
- Amphotericin b liposomal + Ifosfamide Moderate
Frequently asked questions
Can I take Amphotericin b liposomal with Oxaliplatin?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B can cause nephrotoxicity, electrolyte loss and infusion reactions. Oxaliplatin could add to renal or infusion-related problems, but the clinical data supporting this are limited.
How serious is the interaction between Amphotericin b liposomal and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, potassium and magnesium during co-treatment. Watch for infusion reactions such as bronchospasm and hypotension.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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