Drug interactions
Anagrelide + Dofetilide
Severity: Major
Anagrelide and Dofetilide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide is a potent QT-prolonging class III antiarrhythmic with a significant torsades de pointes risk, and anagrelide adds to this risk. Together they may produce dangerous ventricular arrhythmias.
What this interaction means in plain words
Anagrelide and Dofetilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Dofetilide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic prolongation of the QT interval through potassium channel effects.
What to do
Avoid the combination; use an alternative to anagrelide in patients requiring dofetilide. If unavoidable, monitor the ECG closely in a monitored setting and maintain normal electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Anagrelide with Dofetilide?
MediHelp rates the interaction as major. Anagrelide and Dofetilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dofetilide is a potent QT-prolonging class III antiarrhythmic with a significant torsades de pointes risk, and anagrelide adds to this risk. Together they may produce dangerous ventricular arrhythmias.
How serious is the interaction between Anagrelide and Dofetilide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative to anagrelide in patients requiring dofetilide. If unavoidable, monitor the ECG closely in a monitored setting and maintain normal electrolytes.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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