Drug interactions
Apalutamide + Chloroquine
Severity: Moderate
Apalutamide and Chloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and may lower chloroquine exposure, which is partly metabolized by CYP3A4 and CYP2C8. This could reduce antimalarial or antirheumatic efficacy.
What this interaction means in plain words
Apalutamide and Chloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Chloroquine belongs to Anti Parasitic.
Why it happens
Induction of CYP enzymes by apalutamide increases chloroquine clearance.
What to do
Monitor for loss of chloroquine efficacy and consider an alternative agent when treating malaria.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Chloroquine?
MediHelp rates the interaction as moderate. Apalutamide and Chloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and may lower chloroquine exposure, which is partly metabolized by CYP3A4 and CYP2C8. This could reduce antimalarial or antirheumatic efficacy.
How serious is the interaction between Apalutamide and Chloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of chloroquine efficacy and consider an alternative agent when treating malaria.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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