Drug interactions
Apalutamide + Colchicine
Severity: Moderate
Apalutamide and Colchicine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide, a strong CYP3A4 inducer and P-gp inducer, may lower colchicine exposure. Gout flare or familial Mediterranean fever control may be lost.
What this interaction means in plain words
Apalutamide and Colchicine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Colchicine belongs to Genitourinary.
Why it happens
Induction of CYP3A4 and P-glycoprotein increases colchicine clearance and reduces absorption.
What to do
Monitor for loss of colchicine efficacy and adjust the dose according to response. Consider an alternative if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Colchicine?
MediHelp rates the interaction as moderate. Apalutamide and Colchicine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide, a strong CYP3A4 inducer and P-gp inducer, may lower colchicine exposure. Gout flare or familial Mediterranean fever control may be lost.
How serious is the interaction between Apalutamide and Colchicine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of colchicine efficacy and adjust the dose according to response. Consider an alternative if control is inadequate.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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