Drug interactions
Apalutamide + Estradiol
Severity: Moderate
Apalutamide and Estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may lower estradiol concentrations, reducing efficacy of hormone therapy and for contraceptive formulations possibly causing breakthrough bleeding or contraceptive failure.
What this interaction means in plain words
Apalutamide and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Estradiol belongs to Endocrine.
Why it happens
CYP3A4 induction increases estradiol metabolism.
What to do
Monitor for loss of symptom control and consider a higher estradiol dose; use a non-hormonal or additional contraceptive method if relevant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Apalutamide with Estradiol?
MediHelp rates the interaction as moderate. Apalutamide and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may lower estradiol concentrations, reducing efficacy of hormone therapy and for contraceptive formulations possibly causing breakthrough bleeding or contraceptive failure.
How serious is the interaction between Apalutamide and Estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and consider a higher estradiol dose; use a non-hormonal or additional contraceptive method if relevant.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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