Drug interactions
Apalutamide + Fexofenadine
Severity: Minor
Apalutamide and Fexofenadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is an enzyme and transporter inducer and may lower fexofenadine exposure, which relies on OATP and P-gp transport. Reduced antihistamine effect is possible but is generally modest.
What this interaction means in plain words
Apalutamide and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Fexofenadine belongs to Respiratory.
Why it happens
Induction of intestinal and hepatic transporters (P-gp, OATP) by apalutamide, reducing fexofenadine exposure.
What to do
Monitor for reduced allergy symptom control. Increase the dose within labeled limits or choose another antihistamine if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Fexofenadine?
MediHelp rates the interaction as minor. Apalutamide and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide is an enzyme and transporter inducer and may lower fexofenadine exposure, which relies on OATP and P-gp transport. Reduced antihistamine effect is possible but is generally modest.
How serious is the interaction between Apalutamide and Fexofenadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced allergy symptom control. Increase the dose within labeled limits or choose another antihistamine if needed.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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