Drug interactions
Apalutamide + Glipizide
Severity: Moderate
Apalutamide and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide can lower glipizide exposure because it induces CYP2C9, the main enzyme that clears glipizide. This may reduce the glucose-lowering effect and lead to worsened glycemic control.
What this interaction means in plain words
Apalutamide and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Glipizide belongs to Endocrine.
Why it happens
Apalutamide induces CYP2C9, increasing the metabolic clearance of glipizide.
What to do
Monitor blood glucose after starting or stopping apalutamide and increase the glipizide dose if control worsens. Reduce the dose again if apalutamide is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Glipizide?
MediHelp rates the interaction as moderate. Apalutamide and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide can lower glipizide exposure because it induces CYP2C9, the main enzyme that clears glipizide. This may reduce the glucose-lowering effect and lead to worsened glycemic control.
How serious is the interaction between Apalutamide and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping apalutamide and increase the glipizide dose if control worsens. Reduce the dose again if apalutamide is discontinued.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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