Drug interactions
Apalutamide + Lacosamide
Severity: Minor
Apalutamide and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide, a strong CYP3A4 inducer, may modestly reduce lacosamide exposure. Lacosamide has multiple clearance pathways, so the effect is usually limited.
What this interaction means in plain words
Apalutamide and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Lacosamide belongs to Central Nervous System.
Why it happens
CYP3A4 and CYP2C19 induction by apalutamide slightly increases the metabolism of lacosamide.
What to do
Monitor seizure control and adjust the lacosamide dose if breakthrough seizures occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Lacosamide?
MediHelp rates the interaction as minor. Apalutamide and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide, a strong CYP3A4 inducer, may modestly reduce lacosamide exposure. Lacosamide has multiple clearance pathways, so the effect is usually limited.
How serious is the interaction between Apalutamide and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and adjust the lacosamide dose if breakthrough seizures occur.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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