Drug interactions
Apalutamide + Lenvatinib
Severity: Minor
Apalutamide and Lenvatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenvatinib is a minor BCRP and P-gp substrate and is partly cleared by CYP3A4. Apalutamide might reduce lenvatinib exposure, but the clinical effect is likely small.
What this interaction means in plain words
Apalutamide and Lenvatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Lenvatinib belongs to Oncology.
Why it happens
Apalutamide weakly induces BCRP, P-gp and CYP3A4, which may lower lenvatinib exposure.
What to do
No dose change is required. Monitor tumor response and blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Apalutamide with Lenvatinib?
MediHelp rates the interaction as minor. Apalutamide and Lenvatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenvatinib is a minor BCRP and P-gp substrate and is partly cleared by CYP3A4. Apalutamide might reduce lenvatinib exposure, but the clinical effect is likely small.
How serious is the interaction between Apalutamide and Lenvatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Monitor tumor response and blood pressure.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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